Neuroinflammation and fractalkine signaling in Alzheimer’s disease
نویسندگان
چکیده
منابع مشابه
Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimers Disease: The NF-kappa B Connection
Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription fac...
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Fractalkine is a chemokine, which has been shown to play important roles in metabolic disease in both animal models and humans. Fractalkine is a key player in the accumulation of atherosclerotic plaques, and fractalkine receptor (CX3CR1) mutations have been implicated in obesity. Serum fractalkine levels have been found to be elevated in type 2 diabetic patients, but the role of fractalkine sig...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2019
ISSN: 1742-2094
DOI: 10.1186/s12974-019-1412-9